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New hope for Parkinson’s patients

Sep 21, 2012, 12.55AM IST TNNJayanta Gupta ]

KOLKATA: Homemaker Chandra Sanyal's world came crashing down a few years ago after doctors diagnosed her slowness of movement, tremors and stiffness/rigidity of limbs as the first stages of Idiopathic Parkinson's Disease. Would she be reduced from a healthy human being to a bedridden wreck, depending on medicines and physical support for even basic needs?

While the news put Chandra into depression, Sk Salauddin, Zafar Ahmed and Chandra Sekhar Bhowmick started considering premature retirement after being diagnosed with Parkinson's.

But the disease failed to get the better of them. Chandra has gone back to her household chores, while the remaining three have put their retirement plans on hold - courtesy a surgical intervention that is now available in Kolkata.

If you thought that pacemakers were used only for hearts requiring electrical impulses, think again. Neurosurgeons in Kolkata have started using pacemakers on Parkinson's patients. The gadget not only reduces the patient's dependence on medication, it also allows him or her spend more time in a day without the tremors and stiffness associated with the disease.

"I thought that my normal life had come to an end till I met neurosurgeon Sujoy K Sanyal at the Rabindranath Tagore Hospital. Today, I lead a normal life and no longer have to depend on others for every need," Chandra said.

Sanyal is the one who pioneered in brain pacemakers in Kolkata several years ago. A couple of years ago, Medica Superspecialty Hospital in the city started annual workshops with neurosurgeons from abroad. It was during these workshops in 2010 and 2011 that Parkinson's patients got the pacemakers fitted.

The pacemaker has worked like magic for Bhowmick. The bank employee from Panskura in East Midnapore, who had been bedridden for nearly two months before the surgery, is now planning to rejoin office.

"Initially, the symptoms are mild and the patients respond to medicine. In fact, initial response to medicine is almost a diagnostic hallmark of Idiopathic Parkinson's Disease. When Chandra and the others came to me, I suggested that they undergo Deep Brain Stimulation (DBS) surgery. In this procedure, electrodes connected to electrical leads are inserted into the 'subthalamic nucleus' of the brain. These are then connected to a pacemaker that sends controlled impulses to the brain. After DBS, Parkinson's patients need to take fewer medicines. Their drug-induced abnormal movement (Dyskinesias) also goes down significantly. There is a complete change in the quality of life," Sanyal said.

DBS is an expensive procedure. According to surgeons, the major chunk of the cost goes towards the pacemaker. Neurosurgeon L N Tripathy of Medica spoke of lesional surgery which is cheaper (nearly a third of the cost involved in DBS). In this procedure, the thalamus inside the brain is actually 'burnt' by inserting electrodes. "Surgeons need to be extremely careful as this is a non-reversible process," Tripathy added.

Sanyal, too, is not in favour of lesional surgeries. According to him, the good effects last barely a few months and the patients can't go in for DBS after that. The neurosurgeon is now making efforts to raise a corpus for poor patients who may require DBS.

Patients who undergo DBS require post-operative pacemaker programming and medicine adjustment. The voltage, pulse width and frequency of simulation of the pulses from the pacemaker has to be monitored and controlled frequently immediately after the surgery and this is why patients need to be close to their doctors.

"The pacemakers nowadays are rechargeable and don't need to be changed every four to five years. The batteries inside can be recharged just by placing an antenna on the surface of the skin below which the pacemaker is implanted and connecting them to a power source while the patient watches television or relaxes," Sanyal said.

Thursday, December 4, 2014

Myths made reality, bizarre claims made for ancient India's achievements

HT Correspondent, Hindustan Times  New Delhi, December 04, 2014
First Published: 21:11 IST(4/12/2014) | Last Updated: 02:40 IST(5/12/2014)
India conducted a nuclear test centuries ago; cow urine can cure diabetes and ancient India was adept at genetics and plastic surgery. These and more such incredible achievements datelined ancient India have come from votaries of Hindu culture.
If people with scientific temper are reaching boiling point, in the absence of technology to go back in time to ancient India for verification trips, little noise is being heard from their quarters.
Here is a sample of what is being claimed as 'Indian science'.
Nuking reason
http://www.hindustantimes.com/Images/popup/2014/12/pokhriyal.jpg
File photo of Ramesh Pokhriyal Nishank. (AFP Photo)
The world acknowledges India has conducted two sets nuclear tests: in 1974 and 1998. Ramesh Pokhriyal Nishank, BJP MP from Haridwar and former Uttarakhand chief minister, disagrees. "Today we are talking about nuclear tests. Lakhs of years ago, Sage Kanad had conducted a nuclear test. Our knowledge and science do not lack anything," Nishank told Parliament. Nishank also batted for astrology, saying it is the topmost science in the world. He said our ancient astrologers dwarfed all other sciences.
Cow urine therapy
Promoting cow urine is a priority for the Rashtriya Swayamsevak Sangh (RSS), seen as the BJP's spiritual and ideological guide. It was reported in May that Madhya Pradesh-based promoters of medicines produced using cow urine or 'gau-mutra' hope that a BJP government at the Centre will help their business.
The RSS is keen on promoting a soft drink made from cow's urine, mixed with products such as aloe vera and gooseberry to fight diseases. "Cow urine offers a cure for around 70 to 80 incurable diseases like diabetes. All are curable by cow urine," said Om Prakash, head of the RSS's cow protection department, in 2009.
Faith in astrology
http://www.hindustantimes.com/Images/popup/2014/12/irani.jpgFile photo of Smriti Irani. (Raj K Raj/HT Photo)
Union HRD Minister Smriti Irani will one day be the country's president: that prediction came from the BJP politician's astrologer in Bhilwara, Rajasthan. "She will become president... in five years," the astrologer told reporters last month after Irani's visit. Irani was asked about her faith in astrology when she is in charge of education. "What I am doing in my personal life is not the responsibility of media to report until and unless it affects my duties," she replied.
Karna a product of genetic engineering
Prime Minister Narendra Modi, speaking at the inauguration of a hospital in Mumbai in October, equated birth of Mahabharata's Karna to genetic engineering. He said, "We can feel proud of what our country achieved in medical science at one point of time. We all read about Karna in Mahabharata. If we think a little more, we realise that Mahabharata says Karna was not born from his mother's womb. This means that genetic science was present at that time. That is why Karna could be born outside his mother's womb."
Ganesha plastic surgery
At the same event, Modi also said, "We worship Lord Ganesha. There must have been some plastic surgeon at that time who got an elephant's head on the body of a human being and began the practice of plastic surgery."
Dinanath Batra claims stem cell research invented by an Indian
In his book Tejomay Bharat, Dinanath Batra, convenor of Shiksha Bachao Andolan Samiti, claimed stem cell research was invented by an Indian, Dr Ganpat Matapurkar, who was inspired by the Mahabharata.
Sanal Edamaruku, president of Indian Rationalist Association, said people need to differentiate between "myth and reality. "Myths are there in all parts of the world and in all cultures; if we can't differentiate myth and reality, something is seriously wrong," said Edamaruku in an e-mail from Helsinki.
Article 51A of the Constitution says Indian citizens have the duty to 'develop the scientific temper, humanism and the spirit of inquiry and reform'. It's an article that our elected representatives must remember--they are sworn to uphold the Constitution.     
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Here's what makes you sensitive to touch

Daily News & Analysis - ‎10 hours ago‎
Scientists have revealed that they have identified the "mechanoreceptor" protein that mediates the sense of touch in mammals.

Tuesday, November 18, 2014

Brain retains "lost" mother tongue traces: Scientists



Brain retains "lost" mother tongue traces: Scientists
LONDON: Scientists have shown the first neural evidence that traces of a "lost" language remain in the brain. 

An infant's mother tongue creates neural patterns that the unconscious brain retains years later even if the child totally stops using the language, according to a new joint study by scientists at the Montreal Neurological Institute and Hospital - The Neuro and McGill University's Department of Psychology. 

"The infant brain forms representations of language sounds, but we wanted to see whether the brain maintains these representations later in life even if the person is no longer exposed to the language," says Lara Pierce, a doctoral candidate at McGill University and first author on the paper. 

The Neuro conducted and analyzed functional MRI scans of 48 girls between nine and 17 years old who were recruited from the Montreal area through the Department of Psychology. 

One group was born and raised unilingual in a French-speaking family. The second group had Chinese-speaking children adopted as infants who later became unilingual French speaking with no conscious recollection of Chinese. 

The third group was fluently bilingual in Chinese and French. 

Scans were taken while the three groups listened to the same Chinese language sounds. 

"It astounded us that the brain activation pattern of the adopted Chinese who 'lost' or totally discontinued the language matched the one for those who continued speaking Chinese since birth. The neural representations supporting this pattern could only have been acquired during the first months of life," says Pierce. 

"This pattern completely differed from the first group of unilingual French speakers." 

The study suggests that early-acquired information is not only maintained in the brain, but unconsciously influences brain processing for years, perhaps for life - potentially indicating a special status for information acquired during optimal periods of development. This could counter arguments not only within the field of language acquisition, but across domains, that neural representations are overwritten or lost from the brain over time. 

The implications of this finding are far reaching, and open the door for questions relating both to the re-learning of an early acquired, but forgotten, language or skill, as well as the unconscious influence of early experiences on later developmental outcomes. 
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High Salt Intake Affects Kidney Directly, says Study


It is known that high salt intake is injurious to health, especially for those withcardiovascular problems but new studies have shown that more sodium affects kidney directly.
New research found that an average intake of 4.7 grams a day is enough to increase therisk of damaging kidney to the extent of needing dialysis, while average is about 2g a day.
"As dietary modification is a low-cost, simple intervention, it offers the potential to significantly reduce the burden from chronic kidney disease, while also protecting fromcardiovascular disease," said Andrew Smyth from the National University of Ireland, Galway. The study second the findings of another study on Chinese recently.
The second study was conducted on 544,635 participants in 120 Chinese villages over a period of 18 months with high and low salt intakel levels. It has substantiated the previous finding that reducing salt intake reduces albuminuria, or excess protein in the urine leading to kidney dysfunction.
The study on Chinese villagers was led by Meg Jardine from the George Institute for International Health in Australia and her colleagues has shown that those who went for reduced sodium intake had a 33% decrease in the likelihood of having albuminuria compared with those without the reduction in salt intake.
All these findings were made during the presentation of papers at the American Society of Nephrology’s Kidney Week conducted from Nov 11 to 16 in Philadelphia, Pennsylvania.
[tags, salt, sodium, intake, harmful, kidney, albuminuria,

Monday, November 17, 2014

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10 seconds of intimate kiss leads to transfer of 80 million bacteria

Times of India - ‎55 minutes ago‎
LONDON: A long intimate kiss has now been found to do more that make your blood race. Scientists have found that a 10 second kiss leads to the transfer of as many as 80 million bacteria between partners.